An informal discussion, led by Joachim Krug, of some recent papers on inferring fitness landscapes, focusing on the first of the three papers below.

Otwinowski J, Plotkin JB. Inferring fitness landscapes by regression produces biased estimates of epistasis.

Otwinowski J, Nemenman I (2013) Genotype to Phenotype Mapping and the Fitness Landscape of the E. coli lac Promoter. PLoS ONE 8(5): e61570. doi:10.1371/journal.pone.0061570

Kouyos RD, Leventhal GE, Hinkley T, Haddad M, Whitcomb JM, et al. (2012) Exploring the Complexity of the HIV-1 Fitness Landscape. PLoS Genetics 8:e1002551. doi: 10.1371/journal.pgen.1002551

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