Spring 2016

Personal Transcription Factor Binding Site Mutations Point to Personal Medical Histories

Wednesday, Mar. 9, 2016 2:00 pm2:30 pm PST

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Calvin Lab

I will show that erosion of gene regulation by mutation load appears to significantly contribute to observed heritable phenotypes that manifest in the medical history. The test I will introduce exposes a hitherto hidden layer of personal variants that promise to shed new light on human disease penetrance, expressivity and the sensitivity with which we can detect them.